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. Author manuscript; available in PMC: 2021 Mar 5.
Published in final edited form as: Neuron. 2019 Jun 20;103(4):673–685.e5. doi: 10.1016/j.neuron.2019.05.037

Figure 7: Scn2a haploinsufficiency impairs synaptic plasticity.

Figure 7:

A: Recording configuration for burst-based LTP experiments. Stimulating electrode was placed in layer 1 and synaptic stimulation was paired with somatic current-evoked AP bursts.

B: Example of EPSPs before and after LTP pairing protocol. Lighter shades are post-induction data (15–25 minutes after pairing). Stimulus artifact removed for clarity.

C: EPSP slope (first 2 ms), membrane potential (Vm) and input resistance (Rin) vs time before and after LTP induction. Circles and bars are mean ± SEM.

D: EPSC slope per cell in Scn2a+/+ cells with and without TTX and Scn2a+/− cells. *: p = 0.0002, Kruskal-Wallis test; WT vs Scn2a+/−: p = 0.0007, WT vs TTX: p = 0.002, Dunn’s multiple comparisons test.