Table 5.
Details of subsequent procedures in eyes with complications in the chronic phase of Stevens-Johnson syndrome/toxic epidermal necrolysis
| Group I: | Group II: | P value | |
|---|---|---|---|
| Procedures in the chronic phase of SJS/TEN | Eyes with acute SJS/TEN before January 2008, n (%), (total n = 18 eyes of 9 patients) | Eyes with acute SJS/TEN after January 2008, n (%), (total n = 78 eyes of 39 patients) |
|
| PROSE lenses | 7/18 (39) | 22/78 (28) | 0.51 |
| Punctal plugs | 2/18 (11) | 7/78 (9) | 0.84 |
| Surgical procedures | |||
| Punctal cautery | 2/18 (11) | 6/78 (8) | 0.74 |
| Cyanoacrylate glue* | 3/18 (17) | 0/78 (0) | 0.01 |
| AMT in chronic phase | |||
| Number of eyes | 8/18 (44) | 1/78 (1) | <0.001 |
| Number of procedures | 22 | 2 | |
| Fornix reconstruction with AM | |||
| Number of eyes* | 3/18 (17) | 0/78 (0) | 0.01 |
| Number of procedures | 5 | 0 | |
| Lid margin mucous membrane graft | 2/18 (11) | 8/78 (10) | 0.92 |
| Surgery for entropion | 8/18 (44) | 4/78 (5) | 0.006 |
| Tectonic PK | |||
| Number of eyes* | 5/18 (28) | 0/78 (0) | 0.003 |
| Number of procedures | 9 | 0 | |
| Patch graft* | 1/18 (6) | 0/78 (0) | 0.19 |
| KLAL* | 2/18 (11) | 0/78 (0) | 0.04 |
| Lr-CLAL* | 1/18 (6) | 0/78 (0) | 0.19 |
| Boston type 1 keratoprosthesis | |||
| Number of eyes* | 4/18 (22) | 0/78 (0) | 0.01 |
| Number of procedures | 9 | 0 | |
| Boston type 2 keratoprosthesis | |||
| Number of eyes* | 1/18 (6) | 0/78 (0) | 0.19 |
| Number of procedures | 3 | 0 | |
| Subsequent glaucoma procedures | |||
| Number of eyes* | 5/18 (28) | 0/78 (0) | 0.003 |
| Number of procedures | 8 | 0 | |
| Subsequent retinal procedures | |||
| Number of eyes* | 4/18 (22) | 0/78 (0) | 0.01 |
| Number of procedures | 5 | 0 | |
| Enucleation* | 2/18 (11) | 0/78 (0) | 0.04 |
SJS = Stevens-Johnson syndrome; TEN = toxic epidermal necrolysis; PROSE = prosthetic replacement of the ocular surface ecosystem; AMT = amniotic membrane transplantation; PK = penetrating keratoplasty; KLAL = keratolimbal allograft; lr-CLAL = living-related conjunctival-limbal allograft
*
Generalized estimated equations (GEE) were used to calculate p values where possible as explained in the text. When GEE could not be used, Fisher’s exact test was done using one eye of each patient for statistical purposes. For ease of the reader, each eye of every patient is included here.