Table 3.

Increase in ventricle size and worsening of white matter changes

Characteristic	Increase in ventricle size between MRI 1 and final MRI (n = 15)	No increase in ventricle size between MRI 1 and final MRI (n = 6)	p value	Worsening of white matter changes between MRI 1 and final MRI (n = 7)	Improvement or no change in white matter changes between MRI 1 and final MRI (n = 14)	p value
Treatment/complications before final MRI
Days between MRIs, median (IQR)	22 (14–45)	16 (10–33)	0.424	25 (14–50)	21 (10–32)	0.322
Ventilator days, median (IQR)	42 (37–49)	43 (27–53)	0.85	42 (36–51)	42 (35–52)	0.856
Dialysis, n (%)	8 (53%)	3 (50%)	1	4 (57%)	7 (50%)	1
Cardiac arrest, n (%)	4 (27%)	3 (50%)	0.354	3 (43%)	4 (29%)	0.638
Vitals/laboratories before final MRI
Highest systolic blood pressure (mm Hg),  median (IQR)	176 (167–201)	195 (179–229)	0.791	179 (172–210)	187 (171–206)	0.689
Lowest systolic blood pressure (mm Hg), median (IQR)	83 (71–91)	71 (58–78)	0.154	64 (58–87)	80 (71–86)	0.743
Lowest PaO2/FiO2, median (IQR)	95 (70–126)	80 (64–137)	0.622	122 (77–180)	77 (66–110)	0.149
Highest procalcitonin (ng/mL), median (IQR)	8 (4.6–91.6)	13 (2.6–125)	0.91	6.4 (0.3–120)	12.7 (5.7–63.5)	0.636
Highest CRP (mg/L), median (IQR)	316 (202–396)	322 (244–392)	0.791	333 (189 –396)	314 (239–392)	0.689
Highest IL-6 (pg/mL), median (IQR)	99 (31–164)	66 (35–168)	0.91	38 (12–84)	112 (36–191)	0.094
Highest ferritin (ng/mL), median (IQR)	7169 (3664–21,255)	4161 (2421–5816)	0.154	4330 (2443–14,813)	4761 (3955–20,432)	0.488
Imaging changes
White matter changes worsened, n (%)	5 (33%)	2 (33%)	1	–	–	–
Outcome
Final GCS score for survivors, median (IQR)	6 (6–15)	8 (4–14)	1	6 (3–15)	7 (6–14)	0.281
Death, n (%)	4 (27%)	2 (33%)	1	0 (0%)	6 (43%)	0.61

CRP C-reactive protein, GCS Glasgow coma scale, IL-6 interleukin 6, IQR interquartile range, MRI magnetic resonance imaging