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. 2021 Feb 19;11:599568. doi: 10.3389/fimmu.2020.599568

Figure 1.

Figure 1

(A) Structural proteins of EBOV. EBOV is composed of seven structural proteins: L-protein (L), Virion protein (VP) 40, VP24, VP30, VP35, Glycoprotein (GP), and Nucleoprotein (NP). GP is exposed on the viral envelope. It mediates host cell attachment and cell entry. The nucleocapsid is composed of NP, VP35, and VP24. NP binds the viral genome. The polymerase L and its cofactor VP35 drive genome replication and transcription. VP30 is a transcription factor which is also a component of the nucleocapsid. (B) Genomic structure of EBOV and genetic segments targeted for vaccines. Genes encoding for each structural protein are shown. Interestingly, the GP gene also encodes for soluble GP (sGP) and small soluble GP (ssGP). Licensed vaccines (rVSV-ZEBOV, Ad26.ZEBOV) and most candidate vaccines (ChAd3-EBO-Z, RNA and DNA vaccines) use GP as antigen because antibody responses following a natural infection mainly target GP. Other antigens such as NP or VP40 have been also evaluated in the licensed MVA-BN-Filo and some candidate peptide or virus-like particle (VLP)-based vaccines. Figure created with BioRender.com.