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. 2021 Feb 19;11:599568. doi: 10.3389/fimmu.2020.599568

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Copyright © 2021 Longet, Mellors, Carroll and Tipton

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Preclinical and clinical studies in the search for correlates of protection. Studies of humoral and cellular responses in Evola virus disease (EVD) survivors and in vaccinated individuals is one strategy to establish correlates of protection. However, controlled challenge studies cannot be performed in humans. The second strategy to identify correlates of protection is the analysis of immune responses in challenge animal models, which allows to compare immunity in protected and not protected animals. Figure created with BioRender.