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. 2021 Feb 18;9:622198. doi: 10.3389/fcell.2021.622198

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Copyright © 2021 Lu, Che, Qu, Zheng, Yang, Bao, Li, Wang, Jin, Wang, Xiao, Qi and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pan-cancer analysis among 10 common tumors. (A) Different mRNA expression patterns of four succinylation regulators, CPT1A, KAT2A, SIRT5 and SIRT7, between tumor and normal tissues among 10 common tumors, *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001. (B) Heatmap of HR illustrating the association between each succinylation regulator and survival status in different tumors. Orange modules mean statistically significant HR > 1, blue modules mean statistically significant HR < 1, and white modules represent for the regulators with no significant prognostic prediction value. HR, hazard ratios; ESCA, esophageal carcinoma; STAD, stomach adenocarcinoma; LUSC, lung squamous cell carcinoma; LUAD, lung adenocarcinoma; LIHC, liver hepatocellular carcinoma; KIRP, kidney renal papillary cell carcinoma; KIRC, kidney renal clear cell carcinoma; COAD, colon adenocarcinoma; BRCA, breast invasive carcinoma; BLCA, bladder urothelial carcinoma.