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. 2021 Feb 18;9:622198. doi: 10.3389/fcell.2021.622198

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Copyright © 2021 Lu, Che, Qu, Zheng, Yang, Bao, Li, Wang, Jin, Wang, Xiao, Qi and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Succinylation regulators might impact the expression of some m6A regulators. (A) The bubble diagram displayed of all RNA related GO pathways enriched by up-regulated genes in cluster 2 compared to cluster 3. (B) The circle chart showed top 5 KEGG pathways enriched by up-regulated genes in cluster 2 compared to cluster 3. (C) A brief summary of 32 m6A regulators reported by high-quality articles. (D) The expression patterns of CPT1A, SIRT5, and 5 m6A regulators at protein level between ccRCC and normal tissues (Wilcoxon test), *P < 0.05, ****P < 0.0001. (E) The Spearman correlation analysis between the expression of CPT1A and 5 m6A regulators at protein level. (F) The Spearman correlation analysis between the protein expression of SIRT5 and 5 m6A regulators at protein level. GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes.