Figure 2.
IDO1 levels and the KYN/TRP ratio were increased in the sera and hippocampi of epileptic mice. (A,B) IDO1 levels in the sera and hippocampi of epileptic mice were evaluated by ELISA. (C,D) The KYN/TRP ratio in the sera and hippocampi of epileptic mice is shown. (E) Double immunofluorescence showing colocalization between IDO1 and GFAP or Iba1 in the hippocampi of epileptic mice (magnification: 400×). The data are presented as the mean ± SEM, n = 3–6 per group. *P < 0.05, **P < 0.01, ***P < 0.001 compared with the control group.
