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. 2021 Feb 18;15:638854. doi: 10.3389/fncel.2021.638854

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Copyright © 2021 Deng, Hu, Hong, Ding, Xiong, Wu and Xie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IDO1 deficiency suppressed seizures in a lithium-pilocarpine-induced epilepsy model. (A) Latency to status epilepticus (SE) onset after pilocarpine injection in the wild-type (WT) group and IDO^−/− group. (B) Spontaneous recurrent seizures (SRS) frequency in the WT group and IDO^−/− group. (C) SRS duration in the WT group and IDO^−/− group. (D) SRS severity in the WT group and IDO^−/− group. The data are presented as the mean ± SEM, n = 10–12 per group. *P < 0.05, ***P < 0.001 compared with the WT group.