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. 2021 Feb 18;15:638854. doi: 10.3389/fncel.2021.638854

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Copyright © 2021 Deng, Hu, Hong, Ding, Xiong, Wu and Xie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IDO1 deficiency reduced the levels of neurotoxic KYN pathway metabolites. (A,B,D,E) LC-MS analysis was used to measure the concentrations of TRP and KYN in the serum and hippocampal tissues of WT and IDO1^−/− mice. (C,F) The KYN/ TRP ratio in the serum and hippocampus is shown. (G,H) LC-MS analysis was used to measure the concentrations of quinolinic acid (QUIN) and kynurenic acid (KYNA) in the hippocampal tissues from WT and KO control and model mice. The data are presented as the mean ± SEM, n = 6 per group. **P < 0.01, ***P < 0.001.