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. 2021 Feb 18;12:618807. doi: 10.3389/fimmu.2021.618807

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Copyright © 2021 Cavagnero, Badrani, Naji, Amadeo, Leng, Lacasa, Strohm, Renusch, Gasparian and Doherty.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Type 1 IFN signaling is required for CDG induced suppression of ILC2s and type 2 inflammation. Wild type, Tmem173-/-, and Ifnar1-/- mice were challenged using the same model as in Figure 1A. (A) Total number of BAL eosinophils (left) and representative plots (right). (B) Total number of BAL neutrophils (left) and representative flow plots (right). (C) Total number of lung eosinophils. (D) Total number of lung neutrophils. (E) Total number of IL-13+ST2+CD127+ ILC2s (left) and representative flow plots (right). Data shown are representative of 5 independent experiments with 13 mice per group. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, unpaired t-test.