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. 2021 Feb 18;9:595159. doi: 10.3389/fcell.2021.595159

FIGURE 2.

FIGURE 2

Structure of USP4. (A) Schematic illustration of the domain organization of USP4 in detail. The position of the catalytic residues (C, H, D) is indicated in red. SL spans residues 385–392; BL1 and BL2 span residues 831–834 and 874–880, respectively. Cartoon representation of (B) USP4-D1D2 domain crystal structure and (C) USP4 DUSP-UBL dimer structure are colored as in (A). The catalytic triad and zinc-coordinating residues are represented as sticks. Dotted lines indicate the position of the USP4 insert.