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. 2021 Mar 5;16(3):e0248206. doi: 10.1371/journal.pone.0248206

Fig 4. Characteristics of serum extracellular vesicles from 14 patients and the quantification of selected miRNA levels in extracellular vesicles.

Fig 4

(A) A representative electron microscopic image of extracellular vesicles from the serum of an LSQCC patient. (B) Results of nanoparticle characterization analysis demonstrating the number of extracellular vesicles and their size distribution. (C) The protein contents of extracellular vesicles from an LSQCC and MSQCC patients were assayed by western blotting and were confirmed to express the common exosome marker CD9. (D) MiR-10a (p = .042), miR-28 (p = .041), and miR-3120 (p = .047) levels in extracellular vesicles were significantly elevated in LSQCC patients compared with MSQCC patients. miRNA, microRNA; LSQCC, lung squamous cell carcinoma; MSQCC, metastatic tumors from head and neck squamous cell carcinoma.