Figure 6.

The reduction of lung inflammation in fibrotic mice with Dex-L-MVs. (A,E) The thickness changes of lung vascular wall with H&E staining after administration and qualification by ImageJ. Scale bar: 100 μm. (B,F) The inflammation and the alveolar structure of lung with H&E staining and qualification analyses. Scale bar: 100 μm. (C,G) The macrophage labeled with F4/80 (red channel) in lung tissue using immunofluorescence. Scale bar: 50 μm. (D) and (H) The M2 macrophage labeled by CD206 with immunohistochemistry. Scale bar: 100 μm. All experiments were performed in triplicate, each being repeated at least three times. Values shown are Representative images mean ± S.D. ^##p < 0.01, ^###p < 0.001, vs. control group, *p < 0.05; **p < 0.01, ***p < 0.001, vs. Model group.