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. 2021 Feb 25;2021:8819231. doi: 10.1155/2021/8819231

Figure 1.

Figure 1

Resveratrol inhibited platelet spreading and TLR4, MMP3, and MMP9 expression in ox-LDL-activated platelets. (a, b) Platelets were treated with or without resveratrol (100 μM) for 10 min, and then, ox-LDL (0.1 mg/ml) was added for another 10 min. (a) Immunofluorescence analysis of platelet spreading. (b) Flow cytometry analysis of TLR4 expression on the platelet membrane. (c) Protein levels of TLR4, MMP3, and MMP9 were analyzed by Western blot. (d) MMP3 secretion in platelets was measured by using an ELISA kit. (e) MMP9 secretion in platelets was measured by using an ELISA kit. The data represent three independent experiments. #p < 0.05, ##p < 0.01, significant difference between non-ox-LDL-treated platelets and ox-LDL-treated platelets; ∗p < 0.05, ∗∗p < 0.01, significant difference between resveratrol-treated platelets and ox-LDL-treated platelets alone.