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. 2021 Feb 25;2021:8819231. doi: 10.1155/2021/8819231

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Copyright © 2021 Yun Xue et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Resveratrol reversed the ox-LDL-induced binding of Syk/NLRP3 and TLR4 in activated platelets. The binding of Syk/NLRP3 and TLR4 was analyzed by coimmunoprecipitation. Rabbit IgG was used as a nonimmune control. Input represents whole platelet lysate. (a) Anti-phosphorylated Syk antibody precipitated phosphorylated Syk/NLRP3 and TLR4 in ox-LDL-activated platelets, which was reversed by resveratrol. (b) Anti-NLRP3 antibody precipitated phosphorylated Syk/NLRP3 and TLR4 in ox-LDL-activated platelets, which was reversed by resveratrol. The data represent three independent experiments.