Table 6. Grades of Recommendation [91].

Grades	Recommendation
A	Strong evidence for efficacy with a substantial clinical benefit, strongly recommended.
B	Strong or moderate evidence for efficacy but with a limited clinical benefit, generally recommended.
C	Insufficient evidence for efficacy or benefit does not outweigh the risks or disadvantages (adverse events, costs), optional.
D	Moderate evidence against efficacy or for adverse outcome, generally not recommended.
E	Strong evidence against efficacy or for adverse outcome, never recommended.