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. Author manuscript; available in PMC: 2021 Mar 6.
Published in final edited form as: Nat Rev Dis Primers. 2020 Jul 16;6(1):58. doi: 10.1038/s41572-020-0188-7

Fig. 2 |. Variability in baseline QTc.

Fig. 2 |

Distribution of the duration of heart rate corrected QT interval (QTc) in individuals who carry the same KCNQ1 mutation and who belong to a LQT1 South African founder population. The vertical dashed line represents the upper limit of normal values for men (440 ms). If the QTc prolongation were determined only by the A341V mutation, the QTc values should be uniformly prolonged with modest variability. The large spectrum of QTc values points to the presence of additional variants affecting ventricular repolarization. Data from REF.12.