Table 1.
Summary of studies with ONSD cut-off for detecting raised ICP in brain infection.
| Study | Patient group | No. of patients | Reference for raised ICP | ONSD cut off [mm] | Sensitivity [%] | Specificity [%] | Country |
|---|---|---|---|---|---|---|---|
| Nabeta, 2014 [45] | Meningitis, 81% cryptococcal. 4% TB meningitis, 15% other/ unknown. Adult population. | 98 | CSF pressure by lumbar puncture | 5.0 | 85 | 59 | Uganda |
| Shirodkar, 2014 [51] | Mixed infective and non-infective pathology. Adult population. |
101 | CT/MRI | 4.6 [F] 4.8 [M] |
84.6 [F] 97.4 [M] | 100 [F] 100 [M] | India |
| Rehman, 2018 [52] | Mixed infective and non-infective pathology. Paediatric population. |
48 | CT/MRI | 4–5.4 [<1y / >10y] |
100 | 60–67 | Pakistan |
| Gupta, 2019 [53] | Mixed infective and non-infective pathology. Adult population. |
100 | CSF pressure by lumbar puncture | 6.3 | 77 | 92 | India |
| du Toit, 2015 [54] | Mixed meningitis. Adult population. | 73 | CSF pressure by lumbar puncture | 4.8 | 50 | 90 | South Africa |
CSF: Cerebrospinal fluid. CT: Computed tomography. F: Female gender. ICP: Intracranial pressure. M: Male gender. MRI: Magnetic resonance imaging. ONSD: Optic nerve sheath diameter ultrasound. TB: Tuberculosis.