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. 2020 Nov 15;23(3):443–450. doi: 10.1038/s41436-020-01009-5

Fig. 1. Fetal fraction amplification (FFA) technology increases fetal fraction (FF) across all body mass index (BMI) levels.

Fig. 1

For 2401 patients who indicated BMI values on the test requisition form, the FF levels measured without FFA (gray circles) and with FFA (purple triangles) are plotted as a function of patients’ BMI values (vertical axis). The top panel plots the histogram of samples with or without FFA. The dotted line is at 4% FF, the threshold below which the American College of Medical Genetics and Genomics (ACMG) considers a sample to have low FF. Three samples are highlighted as illustrative examples that had low FF before FFA but normal FF after FFA. NIPS noninvasive prenatal screening.