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. Author manuscript; available in PMC: 2022 Mar 4.
Published in final edited form as: Cell Stem Cell. 2020 Nov 23;28(3):424–435.e6. doi: 10.1016/j.stem.2020.10.012

Figure 5. Loss of the FA pathway results in impaired epidermal integrity.

Figure 5.

(A) A Negative Pressure Cutaneous Suction System (Electronic Diversities) was applied to consented individuals following IRB approval and time to blister formation was recorded as a measure of skin fragility. Minimal time required for blister formation in the skin of control (n=9) and FA (n=8) populations is graphed. ***P<0.0001. Error bars represent SEM. (B) Working model showing FA versus normal epidermis. Strong desmosome and hemidesmosome connections that normally maintain human epidermal integrity are impaired in the FA skin, in conjunction with weakened cell adhesion and stimulated proliferation phenotypes which may be active contributors to the increased SCC susceptibility observed in FA. See also Figure S5.