TABLE 2.
Univariate and multivariate analysis of DFS
| Univariate | Multivariate | |||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
| Age (≥70/<70) | 2.5059 | 0.9972‐6.2974 | .0507 | |||
| Sex (male/female) | 3.0757 | 1.1404‐8.2949 | .0264 | 4.0486 | 1.3768‐11.9048 | .0110 |
| Hepatitis B virus surface antigen (±) | 0.9516 | 0.3264‐2.7742 | .9277 | |||
| Anti‐hepatitis C virus antibody (±) | 1.3645 | 0.6194‐3.0058 | .4405 | |||
| Child‐Pugh classification (A/B) | 1.0035 | 0.2347‐4.2899 | .9962 | |||
| Alpha‐fetoprotein (≥20/<20 ng/mL) | 0.9471 | 0.4290‐2.0908 | .8931 | |||
| Des‐γ‐carboxy prothrombin (≥100/<100 mAU/mL) | 3.7439 | 1.2798‐10.9525 | .0159 | 3.6223 | 1.1524‐11.3859 | .0276 |
| Tumor size (≥5/<5 cm) | 2.3437 | 1.0475‐5.2438 | .0382 | 1.2664 | 0.4991‐3.2135 | .6190 |
| Number of tumors (multiple/single) | 3.1849 | 1.1738‐8.6416 | .0229 | 3.6273 | 1.0927‐12.0402 | .0353 |
| Histological differentiation (poorly/well, moderately) | 2.3048 | 1.0441‐5.0876 | .0387 | 1.7253 | 0.7344‐4.0532 | .2107 |
| Microscopic portal vein invasion (±) | 1.3128 | 0.5650‐3.0502 | .5269 | |||
| Liver cirrhosis (±) | 1.2455 | 0.5650‐2.7457 | .5861 | |||
| miR‐638 expression (high/low) | 2.6354 | 1.1293‐6.1503 | 00250 | 3.2128 | 1.2972‐7.9567 | .0117 |
CI, confidence interval, DFS, disease‐free survival, HR, hazard ratio, miR, microRNA.