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Relationship between vericiguat PK and a HR over 1 min, b cardiac index, c SVR, d cGMP, e adrenaline, and f noradrenaline. Figures include data from: SD1–2, MD1–3, BA1 (HR over 1 min); SD1, MD2, BA1 (cardiac index and SVR); SD1, MD1–2, BA1 (cGMP); SD1, MD1–2 (adrenaline and noradrenaline). BA, bioavailability; bpm, beats per minute; cGMP, cyclic guanosine monophosphate; HR, heart rate; MD, multiple dose study; PK, pharmacokinetic; SD, single dose study; SVR, systemic vascular resistance
