Table 4.

Pharmacodynamics following multiple oral doses of vericiguat as IR tablets: change from baseline of difference in heart rate over 1 min (day 11 and day − 1), during the 4 h after administration vs placebo (study MD1)

Change from baseline of difference in heart rate over 1 min	Vericiguat dose (IR tablets)
	1.25 mg	5.0 mg	7.5 mg	10.0 mg
Difference: vericiguat vs placebo (bpm)	2.95	3.75	3.75	5.42
95% CI	0.06–5.85	0.41–7.08	0.85–6.65	2.42–8.42
p value	0.046*	0.029*	0.013*	0.001*

*p value < 0.05 bpm, beats per minute; CI, confidence interval; IR, immediate release; MD1, multiple dose study 1