Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Mar 5;7:24. doi: 10.1038/s41523-021-00227-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 4 — We stratified the TCGA(CPTAC) primary BC proteomics data into three groups according to axillary tumour burden (ATB): those who had a sentinel lymph node biopsy only (SLNB; no/low ATB); those who had a completion clearance (CC; higher burden of ATB than the SLNB group); and those who had an axillary lymph node dissection, and high ATB, at diagnosis (ALND). Of the 10 most abundant reactive proteins, ADD1 (p = 0.01; A) and specific ADD1 phospho-isoforms; ASPN (p = 0.02; B) and PRELP (p = 0.023; B) were significantly up-regulated in the SLNB group, matching our data. No metastatic proteins were found to be significantly differentially expressed. Comparison of the perfusate proteome with BC plasma proteomic studies (C) showed minimal overlap, with APOC3 and KRT9 identified as up-regulated in metastatic nodes/perfusate, and SERPIND1 as up-regulated in reactive nodes/perfusate. (Graphs show median with interquartile range).