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. 2021 Mar 5;11:5332. doi: 10.1038/s41598-021-84122-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Association between whole blood FA, serum lipids, serum carnitine- and choline derivatives and RA disease activity. (a) Columns show relative FA concentrations (mean ± SD) grouped by RA disease activity, DAS28 score ≤ 2.6 = RA in remission (N = 33, coloured in blue) or DAS28 ≥ 2.6 = active RA (N = 45, coloured in red) and by chemical classification (SFA, MUFA, PUFA n−6, PUFA n−3) sorted from high to low abundance. (b) Boxplots show FA, lipids, and carnitine- and choline derivatives significant associated with RA disease activity status (RA in remission (N = 33, coloured in blue, active RA (N = 45, coloured in red). The boxplots show medians, the error bars indicate 5–95% confidence interval. The connectors show statistically significant differences, P < 0.05. P values are based on Student t-test.