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. 2021 Mar 5;12:1464. doi: 10.1038/s41467-021-21671-w

Fig. 6. Predicted functions for uncharacterized genes using the Hallmark collection.

Fig. 6

a Boxplot of ICA-TC-based (blue) and PCA-TC-based prediction scores (red) of Corf and LOC genes (n = 835) for the Hallmark gene set collection (x-axis). The vertical lines of boxes correspond to the median prediction scores; hinges correspond to second and third quartiles of the data; whiskers extend up to 1.5 times the interquartile range; outliers are plotted as dots. Center of box corresponds to median. b Heatmap depicting hierarchical clustering of Corfs and LOC genes (n = 835) based on the ICA-TC-based prediction scores for the Hallmark gene set collection. Clusters were obtained with a height cutoff of 0.8, resulting in 116 clusters with a median size of five members. Insets depict two clusters containing Corfs and LOC genes predicted to be involved in DNA repair, and estrogen receptor response. Genes marked with an asterisk have been recently implicated in the predicted biological processes based on experimental work.