Fig. 7. Predictions scores for genes found to be essential for DNA repair in a CRISPR-based screen.

Both the PCA-TC and ICA-TC-based method predictions for Gene Ontology Biological Process gene set GO DNA REPAIR are shown. Genes that belong (orange) or do not belong (blue) to the GO DNA repair gene set are plotted in separate panels. For the case of genes that are not members of a DNA repair gene set, the scatterplot indicates that ICA-TC-based predictions are higher, while PCA-TC-based predictions remain close to zero and are sometimes negative.