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. 2021 Mar 5;4:281. doi: 10.1038/s42003-021-01820-z

Fig. 2. Exposure to processed diet produces a more pronounced alteration of gut fungal communities than does exposure to standardized chow.

Fig. 2

a Experimental schematic. b Compared to healthy mice exposed to a standardized chow diet for 8 weeks, mice exposed to a processed diet show reduced community diversity. While gut fungal communities remained distinctly clustered by vendor, exposure to processed diet for 8 weeks exerted a convergent effect on community composition that exceeded the similar effect of standardized chow (c, d Bray–Curtis dissimilarity distance). Supervised partial least squares discriminant analysis (e) and linear discriminant analysis of effect size (f) confirm key operational taxonomic units and genera driving differences in community composition. Hypothesis testing was performed using ANOVA (b), PERMANOVA (c), and ANOSIM (d). ANOSIM analysis of similarities, CCA canonical correspondence analysis, OTUs operational taxonomic units, LDA linear discriminant analysis, PERMANOVA permutational multivariate ANOVA, PD processed diet, PCA principal components analysis, PCoA principal coordinates analysis, SD standard diet. Schematic created using BioRender.com.