FIGURE 1.

Timeline of experiments conducted involving aged mice. Mice of above five genotypes were aged until sacrifice via cervical dislocation between 12–15 months for glycogen quantification, biochemical assays, immunohistochemistry and histopathology (periodic acid-Schiff diastase staining). For myoclonus testing, mice were 12–15 months old, while kainate-induced epilepsy testing involved mice 12 –16 months old. The number of mice excluded over the course of the experiment and across all genotypes was 18. Reasons for exclusion were various health concerns, or animals found dead, that were not specific to any particular genotype