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Insertion of the Zen-Ub1 cassette into exon 1 of Ppp1r3d for generation of R6KO mice. (a) A Zen-Ub1 cassette consisting of a lacZ-p(A) reporter and a loxP-flanked hUbCpro-neo-p(A) selection marker were inserted into exon 1 for an 836 base pair deletion. (b) Extraction of genomic DNA from brain tissue reveals that exon 1 was replaced with the cassette in R6KO mice
