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. 2020 Sep 25;190(3):439–447. doi: 10.1093/aje/kwaa204

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Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health 2020. This work is written by (a) US Government employee(s) and is in the public domain in the US.

This work is written by US Government employees and is in the public domain in the US.

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Power to discriminate Dirichlet multinomial samples as a function of the multiplier, , that perturbs the parameters for 5 randomly selected phyla, as described in Methods. Results are shown for n = 25 (A), 50 (B), and 100 (C) samples in each group based on Bray-Curtis dissimilarity. The solid locus represents the 2-degrees-of-freedom (df) test (or Hotelling T² test) based on standard reference samples; the dot-dashed locus represents the 5-df test; and the dashed locus represents microbiome regression-based kernel association test (MiRKAT). Power estimates are based on 3,000 independent simulations for each multiplier, 1.0, 1.2, 1.3, and 1.5.

Inline graphic — Power to discriminate Dirichlet multinomial samples as a function of the multiplier, , that perturbs the parameters for 5 randomly selected phyla, as described in Methods. Results are shown for n = 25 (A), 50 (B), and 100 (C) samples in each group based on Bray-Curtis dissimilarity. The solid locus represents the 2-degrees-of-freedom (df) test (or Hotelling T² test) based on standard reference samples; the dot-dashed locus represents the 5-df test; and the dashed locus represents microbiome regression-based kernel association test (MiRKAT). Power estimates are based on 3,000 independent simulations for each multiplier, 1.0, 1.2, 1.3, and 1.5.