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. 2020 Jun 17;113(3):309–317. doi: 10.1093/jnci/djaa087

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© The Author(s) 2020. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Genomic landscape of endocrine-resistant breast cancer in circulating tumor DNA analysis. A) Distribution and number of mutations by patient at baseline. B) Prevalence of mutated genes observed in the baseline plasma samples (n = 331). C) Prevalence of copy number gain from the subset of patients with greater than 10% circulating tumor fraction. D) Associations between clinic-pathological characteristics and ctDNA genomic features. P values calculated with χ² if categorical or Cochran-Armitage tests if ordinal, corrected using Benjamini-Hochberg method. CNV = copy number variant; ctDNA = circulating tumor DNA; ER = estrogen receptor; LN = lymph node.