Table 2.
Changes in the activity levels of Acetylcholinesterase (AChE) in different brain regions of rats during PTZ-induced epilepsy and on Pre-treatment with different extracts of Bacopa monnieri.
| S.No. | Brain area | SC | PTZ | EE + PTZ | nHE + PTZ | CE + PTZ | EAE + PTZ | nBE + PTZ | AE + PTZ | DZ + PTZ |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CC | 4.869{a} | 3.218{b} | 2.064{C} | 6.207{d} | 3.716{e} | 6.338{fd} | 5.009{ca} | 2.583{h} | 7.181{i} |
| ±0.046 | ±0.417 | ±0.043 | ±0.096 | ±0.149 | ±0.086 | ±0.007 | ±0.273 | ±0.065 | ||
| (-33.90) | (-57.60) | (27.47) | (-23.68) | (30.19) | (2.875) | (-46.95) | (47.51) | |||
| [-35.86] | [92.88] | [15.47] | [96.95] | [55.65] | [-19.73] | [123.15] | ||||
| 2 | CB | 5.297{a} | 2.872{b} | 1.549{gb} | 6.396{d} | 3.233{e} | 6.537{fd} | 5.708{fd} | 1.826{hc} | 5.639{iag} |
| ±0.096 | ±0.332 | ±0.154 | ±0.210 | ±0.163 | ±0.188 | ±0.111 | ±0.123 | ±0.022 | ||
| (-45.78) | (-70.75) | (20.72) | (-38.98) | (23.40) | (7.759) | (-65.52) | (6.456) | |||
| [-46.06] | [122.70] | [12.56] | [127.61] | [98.74] | [-36.42] | [96.34] | ||||
| 3 | PM | 5.074{a} | 3.497{b} | 2.734{g} | 5.344{da} | 3.986{e} | 5.477{fd} | 5.603{gdf} | 2.595{hc} | 6.778{i} |
| ±0.065 | ±0.205 | ±0.396 | ±0.030 | ±0.017 | ±0.103 | ±0.092 | ±0.163 | ±0.132 | ||
| (-31.08) | (-46.11) | (25.03) | (-21.44) | (7.963) | (10.42) | (-48.850) | (33.60) | |||
| [-21.81] | [52.81] | [13.98] | [56.61] | [60.22] | [-25.79] | [93.82] | ||||
| 4 | HC | 4.973{a} | 3.017{b} | 2.135{gb} | 6.437{d} | 4.497{e} | 5.313{fa} | 5.997{gd} | 2.993{hb} | 6.935{i} |
| ±0.312 | ±0.004 | ±0.525 | ±0.156 | ±0.118 | ±0.050 | ±0.217 | ±0.012 | ±0.063 | ||
| (-39.33) | (-57.06) | (29.41) | (9.591) | (6.836) | (20.59) | (-39.81) | (39.43) | |||
| [-29.23] | [113.35] | [49.05] | [76.10] | [98.77] | [-0.795] | [129.86] |
All the values are Mean, ±SD of six individual observations. Values with same Superscript is significant at P < 0.05. Values with different Superscript are non-significant at P < 0.05. Values in ‘( )’parentheses are % change over saline control and values in ‘[ ]’ are % change over PTZ treatment.