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CDD-1102 is a potent and selective inhibitor of the second bromodomain of BRDT and BRD4. Competitive inhibition of human BET bromodomain (BRDT-BD1, BRDT-BD2, BRD4-BD1, and BRD4-BD2) binding to biotinylated JQ1 by CDD-1102 and (+)−JQ1 using proximity detection assays. GraphPad Prism software was used to generate inhibition fitting curves and to determine IC50 values.
