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. 2021 Feb 26;118(9):e2021102118. doi: 10.1073/pnas.2021102118

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Copyright © 2021 the Author(s). Published by PNAS.

This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY).

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Fig. 3. — BROMOscan bromodomain profiling of JQ1, CDD-1102, and CDD-1302 on various bromodomains. Phylogenetic tree of bromodomains demonstrating preferential compound binding of CDD-1102 and CDD-1302 for the BET subfamily BD2 domains using the BROMOscan bromodomain competition binding assay performed by the Eurofins DiscoverX Corporation (Top). BromoKdELECT dose–response curves and the calculated binding constants (K_d) confirmed that CDD-1102 and CDD-1302 are strong binders to the BET subfamily BD2 domains, with the highest affinity for BRDT-BD2 (Middle and Bottom). JQ1 binding to both BET bromodomains served as a control in these assays.