Table 1.

Analysis of DEC-Tec hits and predicted library members

^*Observed molecule count in the DEC-Tec screen against BRDT-BD2. A “0” indicates that the compound was theoretically present in the library but was not detected in the sequencing data.

^†IC₅₀ determined using the AlphaScreen assay protocol.

^‡t_1/2 measured using the liver microsomal stability assay; assay data >60 min are an extrapolated estimate and included for relative determination of the half-life.

^§NE: no effect at 10 µM in the AlphaScreen assay.