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GcgR antagonism regenerates functional β-cell mass in PANIC-ATTAC mice. GcgR mAb was provided 12 and 19 d after dimerizer. Glucose (A), insulin (B), and C peptide (C) were measured at routine intervals during recovery, which included a washout period without treatment. Glucose (D) and insulin (E) were measured during an oral glucose tolerance test. Insulin was quantified following an arginine tolerance test (F). (A–C) n = 18; (D–F) n = 9. *P < 0.05. Standard error shown.
