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. 2021 Feb 22;118(9):e2010213118. doi: 10.1073/pnas.2010213118

Fig. 2.

Fig. 2.

FECs of PrP bound to PPS. (A) Schematic of force spectroscopy experiment: A single PrP molecule is attached to beads held in optical traps by DNA handles. (B) Without PPS present, PrP unfolds with a characteristic contour length change of 34.3 nm in a narrow range of forces near 10 pN. (C) With PPS present, PrP unfolds heterogeneously, showing a variety of different contour lengths and unfolding forces. (Inset) The unfolding force distribution with PPS present (cyan) is much broader than without PPS (black).