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Space-filling representation of the two predominant open forms of G614 spike and the predominant closed form of D614 spike. The one- and two-RBD-erect forms of G614 spike make up 87% of particles, while the closed form represents 83% of the D614 spike particles in our previous study (5). The three subunits of spike are colored in blue, goldenrod, and rosy brown for G614 and in lighter shades of the same colors for D614. The molecule is viewed with its long axis vertical.
