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. Author manuscript; available in PMC: 2021 Jul 6.
Published in final edited form as: Mol Pharm. 2020 Jun 11;17(7):2555–2569. doi: 10.1021/acs.molpharmaceut.0c00257

Figure 7.

Figure 7.

Combined chemical rules strongly differentiate between mAbs with different levels of non-specific and self-interactions for an independent set of antibodies. (A) Non-specific interactions (ELISA) and (B) self-interactions (AC-SINS) were measured for 39 mAbs that were not included in the training and test sets used to generate the combined chemical rules. The p-values were calculated using a two sample Anderson-Darling test. In (A), the difference between ⩽3 chemical flags and 4–7 chemical flags is not significant.