Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Mar 6;40:90. doi: 10.1186/s13046-021-01880-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 1 — m⁶A methylation of FBXW7 mRNA by METTL3. a m⁶A abundance on FBXW7 mRNA in HCC827 cells detected by MeRIP. b Gene correlation analysis of FBXW7 and m⁶A enzymes by GEPIA using Spearman statistics in lung adenocarcinoma (LUAD). c Western blotting of FBXW7 and METTL3 in HCC827 cells with METTL3 overexpression or knockdown. d Representative immunohistochemical staining for METTL3 and FBXW7 in LUAD and adjacent normal tissue (scale bar: 250 and 100 μm). e Correlation analysis between FBXW7 and METTL3 in twenty-eight pairs of normal (N) and LUAD tumor (T) samples. Correlation chart drawn in GraphPad Prism Version 8.4.0. Red: tumor; Black: normal. r = 0.4576, p < 0.001. (Pearson’s correlation analysis). Bar = mean ± SD. **p < 0.01