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. 2021 Mar 6;40:90. doi: 10.1186/s13046-021-01880-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Proposed model for the function and mechanism of m⁶A-modified FBXW7 in LUAD. Mechanism of m⁶A-modified FBXW7-inhibited lung adenocarcinoma (LUAD) growth. FBXW7 may function as a tumor suppressor regulated by METTL3, which installs m⁶A modifications in the CDS of FBWX7 mRNA and inhibits cell proliferation, ultimately promoting apoptosis via FBXW7 to suppress growth in LUAD