Table 1.
Novel loci identified for MI through GWAS meta-analysis of the UK Biobank and CARDIoGRAMplusC4D
| MI |
CAD |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| SNP | Chr | Pos | Nearest gene(s) | EA/OA | EAF | OR (95% CI) | P-value | OR (95% CI) | P-value |
| rs113716316 | 1p36.11 | 27 928 640 | AHDC1 | G/A | 0.93 | 1.09 (1.06–1.13) | 4.4 × 10−8 | 1.07 (1.05–1.10) | 5.0 × 10−8 |
| rs12743267 | 1p21.3 | 95 249 306 | SLC44A3 | C/T | 0.77 | 1.05 (1.03–1.07) | 1.1 × 10−8 | 1.03 (1.01–1.04) | 2.0 × 10−4 |
| rs6761276 | 2q13 | 113 832 312 | IL1F10 | T/C | 0.43 | 1.04 (1.03–1.06) | 2.8 × 10−8 | 1.03 (1.01–1.04) | 2.2 × 10−5 |
| rs12693302 | 2q32.1 | 183 211 443 | PDE1A | G/A | 0.39 | 1.05 (1.03–1.06) | 2.5 × 10−9 | 1.03 (1.01–1.04) | 2.5 × 10−5 |
| rs2452009 | 4q22.3 | 95 495 908 | PDLIM5 | A/G | 0.70 | 1.05 (1.03–1.07) | 5.8 × 10−9 | 1.03 (1.02–1.05) | 9.4 × 10−7 |
| rs9486719 | 6q16.1 | 97 060 124 | FHL5 | G/A | 0.80 | 1.06 (1.04–1.08) | 6.8 × 10−10 | 1.04 (1.03–1.06) | 1.1 × 10−8 |
| rs28429551 | 9q34.3 | 139 243 334 | GPSM1 | A/T | 0.76 | 1.06 (1.04–1.08) | 1.7 × 10−8 | 1.04 (1.02–1.05) | 4.0 × 10−6 |
| rs8037798 | 15q24.2 | 75 240 030 | COX5A-RPP25 | G/T | 0.23 | 1.05 (1.03–1.07) | 3.8 × 10−8 | 1.02 (1.01–1.04) | 1.6 × 10−3 |
Chr, chromosome; CI, confidence interval; EA, effect allele; EAF, effect allele frequency; OA, other allele; OR, odds ratio; P, P-value obtained from meta-analysis of the UK Biobank and CARDIoGRAMplusC4D; Pos, base-pair position (hg19).