Table 2.

Comparative associations of the 8 novel loci and the ABO locus with MI and CAD in the UK Biobank

						MI vs. Control (17 505/454 212)		CAD only vs. Control (15 580/454 212)		CAD+/MI+ vs. CAD+/MI− (17 505/15 580)
SNP	Chr	Pos	Nearest gene(s)	EA/OA	EAF	OR (95% CI)	P-value	OR (95% CI)	P-value	OR (95% CI)	P-value
rs113716316	1p36.11	27 928 640	AHDC1	G/A	0.93	1.11 (1.07–1.16)	7.2 × 10−7	1.07 (1.02–1.12)	4.1 × 10−3	1.04 (0.98–1.11)	0.21
rs12743267	1p21.3	95 249 306	SLC44A3	C/T	0.76	1.04 (1.01–1.06)	3.1 × 10−3	1.00 (0.97–1.03)	0.98	1.04 (1.01–1.08)	0.02
rs6761276	2q13	113 832 312	IL1F10	T/C	0.42	1.03 (1.01–1.06)	1.9 × 10−3	1.01 (0.99–1.03)	0.44	1.03 (0.99–1.06)	0.11
rs12693302	2q32.1	183 211 443	PDE1A	G/A	0.36	1.06 (1.03–1.08)	1.3 × 10−6	0.98 (0.96–1.01)	0.19	1.07 (1.04–1.10)	2.9 × 10−5
rs2452009	4q22.3	95 495 908	PDLIM5	A/G	0.70	1.04 (1.02–1.07)	2.6 × 10−4	1.01 (0.98–1.03)	0.68	1.03 (1.001–1.07)	0.04
rs28429551	9q34.3	139 243 334	GPSM1	A/T	0.76	1.07 (1.04–1.10)	4.8 × 10−8	1.01 (0.98–1.03)	0.54	1.07 (1.03–1.11)	2.8 × 10−4
rs8037798	15q24.2	75 240 030	COX5A-RPP25	G/T	0.24	1.05 (1.03–1.08)	3.2 × 10−5	1.00 (0.97–1.02)	0.85	1.06 (1.02–1.10)	1.7 × 10−3
rs9411377	9q34.2	136 145 404	ABO	A/C	0.30	1.06 (1.04–1.09)	3.3 × 10−7	0.99 (0.97–1.02)	0.67	1.07 (1.03–1.10)	1.3 × 10−4

Number of cases and controls for each phenotype defined in the UK Biobank are shown in parentheses.

For CAD⁺/MI⁺ vs. CAD⁺/MI⁻ analyses, cases were defined as subjects positive for both CAD and MI; controls were defined as CAD positive subjects without MI.

Chr, chromosome; CI, confidence interval; EA, effect allele; EAF, effect allele frequency; OA, other allele; OR, odds ratio; P, P-value obtained from linear mixed model analysis in UK Biobank; Pos, base-pair position (hg19).