Figure 2. Store operated Ca2+ entry (SOCE) induced by thapsigargin in Jurkat T cells and the inhibitory effects of α-Mangostin on SOCE.
SOCE was induced with thapsigargin, and the inhibitory effects were confirmed by treatment with 1 µM and 3 mM α-mangostin. BTP2 was used as a positive control. (A) Average trace (n = 18) shows changes in the intracellular calcium signal by α-mangostin in Jurkat T cells stimulated with thapsigargin. (B) Average value at the stabilization point of the calcium signal. The average value of points marked with †. Data are expressed as the mean ± SEM. **** p < 0.0001.