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. 2021 Mar 1;16:1709–1724. doi: 10.2147/IJN.S289707

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© 2021 Zhang et al.

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Metal-homeostasis-related genes (ZIP14 (A), DMT1 (B), FPN (C), SLC30A10 (D), IRP2 (E), FtH (F), Hamp2 (G), and SPCA1 (H)) expression of RAW264.7 cells challenged with Mn-IONPs with different concentrations (0, 45, 90, 180, 360, 900 and 1800 μM) for varied time period (24 hours, 48 hours and 72 hours). The mRNA levels in the control cells (incubated with 0 μM Mn-IONPs) were indicated with red dotted lines. (I) Heat map shows relative changes in all measured mRNA expression with respect to that before the Mn-IONPs challenge.