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. 2021 Mar 6;13(5):360–378. doi: 10.1007/s13238-021-00822-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Model of RSV nuclear entry to inhibit virus replication in vector insect cells. The nucleocapsid protein (NP) and genomic RNAs of RSV are transported to the nuclei of vector insects through binding to three importin α proteins, which are part of the nuclear transport system of vector cells. In nuclei, NP interacts with the transcription factor YY1 and inhibits the transcriptional regulation of YY1 to FAIM. The reduced expression of FAIM activates a caspase-dependent apoptotic response, which inhibits viral replication in the cytoplasm