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. 2021 Mar 1;3(1):zcab004. doi: 10.1093/narcan/zcab004

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© The Author(s) 2021. Published by Oxford University Press on behalf of NAR Cancer.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — InDel and SV patterns associated with BPA and SO exposure in HEK 293T cell line. (A) During replication, bulky DNA adducts with BPA or SO may cause trans-lesion synthesis or replication fork collapse leading to small InDels and/or structural variations; (B) InDel frequency in different genomic, epigenomic, nuclear localization and replication timing contexts in the BPA and SO-treated samples. Relative mutation frequency in respective context is calculated as the number of mutations attributed to the context normalized by the total length of the genomic regions assigned to the context, followed by log10 transformation; (C) Barplots depict InDel spectra in the BPA and SO-treated samples at 83 nucleotide contexts. Data represent mean frequency percentages (±SD) of three BPA and four SO-treated samples. (D) Boxplots show similarity (Pearson correlation coefficient) between mutation spectra observed in the BPA and SO-treated samples with that of the COSMIC small InDel signatures (COSMIC v2); (E) Circos plots show patterns of structural variations in the BPA and SO-treated samples, and also in the DMSO-treated negative control.