Table 2.
Univariable Analysis and Cox Proportional Hazards Regression Analysis
| Characteristics | Univariable Analysis | Multivariable Analysis | ||
|---|---|---|---|---|
| HR (95% CI) | p value | HR (95% CI) | p value | |
| Age (years) | ||||
| <60 | 1 (reference) | |||
| 60–70 | 1.05 (0.91–1.22) | 0.52 | ||
| ≥70 | 1.05 (0.91–1.22) | 0.48 | ||
| Sex | ||||
| Male | 1 (reference) | |||
| Female | 1.09 (0.95–1.24) | 0.21 | ||
| Hepatectomy | ||||
| Minor LR | 1 (reference) | |||
| Major LR | 0.96 (0.85–1.08) | 0.46 | ||
| Size | ||||
| ≤ 2 cm | 1 (reference) | 1 (reference) | ||
| 2–5 cm | 1.41 (1.13–1.76) | 0.002 | 1.38 (1.10–1.71) | 0.006 |
| 5–10 cm | 1.66 (1.31–2.08) | <0.001 | 1.69 (1.34–2.13) | <0.001 |
| > 10 cm | 2.30 (1.78–2.95) | <0.001 | 2.23 (1.73–2.89) | <0.001 |
| Number | ||||
| Single | 1 (reference) | 1 (reference) | ||
| Multiple | 1.50 (1.28–1.78) | <0.001 | 1.64 (1.39–1.94) | <0.001 |
| MVI | ||||
| Negative | 1 (reference) | |||
| Positive | 1.69 (1.49–1.92) | < 0.001 | 1.44 (1.27–1.65) | <0.001 |
| Grade | ||||
| I | 1 (reference) | 1 (reference) | ||
| II | 1.26 (1.08–1.48) | 0.003 | 1.20 (1.03–1.41) | 0.02 |
| III or IV | 1.68 (1.42–1.99) | <0.001 | 1.55 (1.30–1.83) | <0.001 |